An Evaluation of Hepato-protective Activity of Ethanolic Extract of Solanum nigrum with Varying Doses on CCL4 Induced Hepatic Injured Rat
Humayra Zaman Himi
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Md.Mahbubur Rahman
Department of Pharmacy, Stamford University Bangladesh, Dhaka, Bangladesh.
Syed Abir Hasan
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Lia Rose Merry D. Cruze *
Department of Pharmaceutical Sciences, North South University, Plot # 15, Block # B, Bangladesh.
Syeda Taarin Ishraat
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Md. Mustafiz Chowdhury
Department of Pharmacy, University of Chittagong, Bangladesh.
*Author to whom correspondence should be addressed.
Abstract
Herbal medicine, an art form as well as a profession, is the use of herbs and herbal remedies to prevent, treat, or cure sickness. In certain tribes, herbal medicine is also known as herbal remedies. In this investigation, rats were used in the research to examine the lipid profiles of the extract from Solanum nigrum. In the case of SGPT, group 6 showed statistically significant outcomes (p< 0.05), whereas in the case of SGOT, both groups 5 and 6 showed statistically significant outcomes (p< 0.05). In relation to the SGPT and the SGOT, this is being said. Both group 5 and group 6 showed statistically significant amounts of creatinine and urea (p< 0.05) during the renal function test. Group 6 with a dose of 1200 mg/kg showed statistically significant results for high-density lipoprotein (HDL) and low-density lipoprotein (LDL) (p< 0.05). Furthermore, at dosages of 600 mg/kg and 1200 mg/kg, respectively, the triglyceride level in groups 5 and 6 was statistically significant (p< 0.05). There were no results that were deemed statistically significant for total cholesterol.
Keywords: Herbal medicine, Solanum nigrum, HDL, LDL, phytochemicals, herbal medicine, triglyceride, landular organ