A Generous Review: Novel Approaches for Colon Targeted Drug Delivery System
Gopavaram Sumanth
*
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER) – Raebareli, Uttar Pradesh, India.
Pooja Prakash Atpadkar
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER) – Raebareli, Uttar Pradesh, India.
Pandupalli Krishna Reddy
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER) – Raebareli, Uttar Pradesh, India.
Gorthi Nihar
Department of Industrial Pharmacy, JSS Collage of Pharmacy – Mysuru, Karnataka, India.
*Author to whom correspondence should be addressed.
Abstract
The colon is where both systemic and local conveyance of medications can occur. Local conveyance permits site treatment of inflammatory bowel disease, Crohn's illness, ulcerative colitis, and so forth in any case, treatment can be created compelling if the medications can be focused on straightforwardly into the colon, in this way diminishing the systemic adverse effects. A medication should be shielded from degradation to accomplish effective colon targeting delivery, release, and absorption in the upper bit of the gastro intestinal tract (GIT) and afterward to be certain controlled delivery in the proximal colon. Pressure controlled colonic conveyance capsules, CODESTM, and the osmotic controlled medication conveyance are the more up to date advances in particular which are having in vivo site explicitness, and attainability of manufacturing process. To beat previous technique's restrictions new frameworks and advancements have been created for colon targeting. This review gives data about CDDS, new advances, limitations.
Keywords: CDDS, advantages, novel approaches, limitations