Use of Bioequivalence Tests and Its Properties under Different Sampling Techniques
Faryal Basharat
Department of Mathematics and Statistics, Pir Mehr Ali Shah Arid Agriculture University, Rawalpindi, Pakistan.
Nasir Jamal
Department of Mathematics and Statistics, Pir Mehr Ali Shah Arid Agriculture University, Rawalpindi, Pakistan.
Muhammad Hanif
Department of Mathematics and Statistics, Pir Mehr Ali Shah Arid Agriculture University, Rawalpindi, Pakistan.
Usman Shahzad
Department of Mathematics and Statistics, Pir Mehr Ali Shah Arid Agriculture University, Rawalpindi, Pakistan.
*Author to whom correspondence should be addressed.
Abstract
Bioequivalence testing is the initial approach for the analysis of quantitative determination of drugs and their metabolism in biological samples. In this research work its applications was tested and reviewed under different sampling techniques. The basic concept of bioequivalence testing crossover design was used to make assessment of medicine for breast cancer methotrexate and tamoxifen. Effectiveness of methotrexate at initial stage was 2.38 and at advance stage it was 1.85 which means it was 43% effective at initial stage while 38% effective in advance stage. Effectiveness of tamoxifen at initial stage 3.19 at advance stage 3.68 which means it was 52% effective at initial stage while 57% effective in advance stage. The relation of bioequivalence testing and distance base inference was highlighted. An attempt was made to analyze the efficiency of both medicines at initial and advance stage of diagnostic of breast cancer.
Keywords: Bioequivalence tests, quantitative determination, methotrexate, breast cancer.