Adverse Drug Effects and Non-Adherence to Antiretroviral Therapy in Nigeria: A Review

Main Article Content

Mary Obidiya Okuku
Alali Dan-Jumbo

Abstract

Objectives: This review aims to assess the link between adverse drug effects and non-adherence to antiretroviral therapy (ART) among people living with HIV/AIDS (PLWHA) in Nigeria.

Methodology: Databases were searched namely PubMed, Web of science core collection, Science direct, Global Health (CABI) and MEDLINE. Fifteen (15) primary articles (studies carried out in Nigeria) met the inclusion criteria and were selected for the review. The primary articles selected for the review were analyzed and critiqued.

Results: The articles selected for review showed that adverse drug effects is a barrier to adherence to ART.

Conclusion: The review conclude that adverse drug effect is a barrier to adherence to ART among PLWHA in Nigeria and recommends patient education on side effects of ART, the need for regular exercises, eating healthy meals and the need for physicians to simplify the regimen with regards to the amount of medication to take and the timing.

Keywords:
Side effects, adverse effects, non-adherence, antiretroviral, HIV/AIDS, Nigeria.

Article Details

How to Cite
Okuku, M. O., & Dan-Jumbo, A. (2021). Adverse Drug Effects and Non-Adherence to Antiretroviral Therapy in Nigeria: A Review. Asian Journal of Advanced Research and Reports, 15(1), 19-25. https://doi.org/10.9734/ajarr/2021/v15i130354
Section
Review Article

References

World Health Organisation. Surveillance of antiretroviral drug toxicity during pregnancy and breastfeeding. Geneva: World Health Organisation; 2015.

Rajesh R, Sudha V, Varma DM, Sonika S. Association between Medication Adherence Outcomes and Adverse Drug Reactions to Highly Active Antiretroviral Therapy in Indian Human Immunodeficiency Virus-Positive Patients. J Young Pharm. 2012;4(4):250-260.

Rajesh R, Vidyasagar S, Patel N, ManjuVarghese J. Safety Aspects of Antiretroviral Therapy for Management of HIV Infection. J Basic Clin Pharm. 2009; 1(1):47-53.

Mannheimer S, Friedland G, Matts J, Child C, Chesney M. The consistency of adherence to antiretroviral therapy predicts biologic outcomes for human immunodeficiency virus-infected persons in clinical trials. Clin Infect Dis. 2002;34(8): 1115-21.

Nadkar MY, Bajpai, S. Antiretroviral therapy: toxicity and adherence. Journal of the Association of Physicians of India. 2009;57:375-376.

Torres TS, Cardoso SW, Velasque LS, Veloso VG, Grinsztejn B. Incidence rate of modifying or discontinuing first combined antiretroviral therapy regimen due to toxicity during the first year of treatment stratified by age. The Brazilian Journal of Infectious Diseases. 2014;18(1):34-41.

Chesney M. Adherence to HAART regimens. AIDS Patient Care and STDs. 2003;17(4):169-177.

Falang KD, Akubaka P, Jimam NS. Patient factors impacting antiretroviral drug adherence in a Nigerian tertiary hospital. Journal of Pharmacology and Pharmacotherapeutics. 2012;3(2):138-142.

Oku AO, Owoaje ET, Ige OK, Oyo-ita A. Prevalence and determinants of adherence to HAART amongst PLHIV in a tertiary health facility in south-south Nigeria. BMC Infectious Diseases. 2013;13(401):1471-2334.

Onyeonoro UU, Ebenebe UE, Ibeh CC, Nwamoh UN, Ukegbu AU, Emelumadu OF. Adherence to antiretroviral therapy among people living with human immunodeficiency virus / acquired immunodeficiency syndrome in a tertiary health facility in South Eastern Nigeria. Journal of HIV & Human Reproduction. 2016;1(2):58-62.

Suleiman IA, Momo A. Adherence to antiretroviral therapy and its determinants among persons living with HIV/AIDS in Bayelsa state, Nigeria. Pharmacy Practice. 2016;14(1):631-637.

Nduaguba SO, Soremekun RO, Olugbake OA, Barner JC. The relationship between patient-related factors and medication adherence among Nigerian patients taking highly active anti-retroviral therapy. African Health Sciences. 2017; 17(3):738-745.

Bello SI. HIV/AIDS Patients’ Adherence to Antiretroviral Therapy In Sobi Specialist Hospital, IIorin Nigeria. Global Journal of Medical Research. 2011;11(2):17-26.

Muoghalu CO. Factors influencing adherence to anti-retroviral therapy among people living with HIV/AIDS attending the State Hospital, Osogbo, Nigeria. HIV & AIDS Review. 2018;17(4):288-298.

Agu KA, Okojie O, Oqua D, King RC, Omonaiye O, Onuoha C, Isah MA, Iyaji PG. Medication Adherence and Risk Factors for Non-adherence Among Patients Taking Highly active Antiretroviral Therapy. West African Journal of Pharmacy. 2011;22(1):19-26.

Odili VU, Obieche AO, Amibor KC. Adherence to Antiretroviral Therapy and Its Determinants Among HIV-Infected Patients in Nigeria. Journal of Pharmacy Practice. 2017;30(3):291-295.

Chineke HN, Adogu POU, Uwakwe KA, Ewuzie MU. Assessment of level of Adherence to Antiretroviral Therapy among Human Immune Deficiency Virus/acquired Immune Deficiency Syndrome Patients at Imo State University Teaching Hospital, Orlu, Nigeria. Nigerian Journal of General Practice. 2015;13(1):21-25.

Pennap GR, Abdullahi U, Bako IA. Adherence to highly active antiretroviral therapy and its challenges in people living with human immunodeficiency virus (HIV) infection in Keffi, Nigeria. Journal of AIDS and HIV Research. 2013;5(2):52-58.

Okoronkwo I, Okeke U, Chinweuba A, Iheanacho P. Nonadherence Factors and Sociodemographic Characteristics of HIV-Infected Adults Receiving Antiretroviral Therapy in Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria. ISRN AIDS. 2013;2013(2013):1-8.

Olowookere SA, Fatiregun AA, Akinyemi JO, Bamgboye AE, Osagbemi GK. (2008) Prevalence and determinants of nonadherence to highly active antiretroviral therapy among people living with HIV/AIDS

in Ibadan, Nigeria. Journal of Infection in Developing Countries. 2008;2(5):369-372.

Anyaike C, Atoyebi OA., Musa OI, Bolarinwa OA., Durowade KA, Ogundiran A, Babatunde OA. Adherence to combined Antiretroviral therapy (cART) among people living with HIV/AIDS in a Tertiary Hospital in IIorin, Nigeria. Pan African Medical Journal. 2019;32(10):1-12.

Uzochukwu BSC, Onwujekwe OE, Onoka AC, Okoli C, Ugwu NP, Chukwuogo OI. Determinants of non-adherence to subsidized anti-retroviral treatment in Southeast Nigeria. Health Policy and Planning. 2009;24(3):189-196.

Mocroft A, Youle M, Moore A, Sabin CA, Madge S, Lepri AC, Philips AN. (2001) Reasons for modification and discontinuation of antiretroviral: Results from a single treatment centre. AIDS. 2001;15(2):185-194.

Stone VE, Hogan JW, Schuman P, Rompalo AM, Howard AA, Korkontzelou C, Smith DK. Antiretroviral regimen complexity, self-reported adherence, and HIV patients’ understanding of their regimens: Survey of women in the HER study. Journal of Acquired Immune Deficiency Syndrome. 2001;28(2):124-131.

Duran S, Spire B, Raffi F, Walter V, Bouhour D, Journot V, APROCO Study Group. Self-reported symptoms after initiation of a protease inhibitor in HIV-infected patients and their impact on adherence to HAART. HIV Clinical Trials. 2001;2(1):38-45.

Jha AK, Gadgade A, Shenoy AK, Chowta MN, Ramapuram JT. Evaluation of adverse drug reactions in HIV positive patients in a tertiary care hospital. Perspectives in Clinical Research. 2015;6(1):34-38.

Koochak HE, Babaii A, Pourdast A, Golrokhy R, Rasoolinejad M, Khodaei S, Moghadam SRJ, Taheri RR, Seyed ASA. Prevalence of Adverse Drug Reactions to Highly Active Antiretroviral Therapy (HAART) among HIV Positive Patients in Imam Khomeini Hospital of Tehran, Iran. Infectious Disorders Drug Targets. 2017;17(2):116-119.

Li H, Marley G, Ma W, Wei C, Lackey M, Ma Q, Renaud F, Vitoria M, Beanland R, Doherty M, Tucker JD. The Role of ARV Associated Adverse Drug Reactions in Influencing Adherence Among HIV-Infected Individuals: A Systematic Review and Qualitative Meta-Synthesis. AIDS and Behavior. 2017;21(2):341-351.

Polit DF, Becks CT. Nursing Research: Generating and Assessing Evidence for Nursing Practice. 9th ed. Philadelphia: Wolters Kluwer / Lippincott Williams and Wilkins; 2012.

Bond W, Hussar DA. Detection of methods and strategies for improving medication compliance. American Journal of Public Health. 1991;48(9):1978-1988.

Nyanzi-Wakholi B, Lara AM, Munderi P, Gilks C. The charms and challenges of antiretroviral therapy in Uganda: the DART experience. AIDS Care. 2012;24: 137-142.