Role of Vitamin E in Prevention of Breast Cancer: An Epidemiological Review

Main Article Content

Md. Sajjadul Haque Ripon
Mohammad Asadul Habib
Miraz Hossain
Nadim Ahmed
Tanbir Kibria
Shirajum Munira
Kamrul Hasan

Abstract

Breast cancer rates are so high among women in more developed countries, rates are increasing in almost every region of the world. In 2018, it is reported that 627,000 women died from breast cancer. Vitamin E is a common supplement characterized by its antioxidant potential effects on many chronic conditions that prevent free radicals from harming DNA, protein and cell membranes may serve as a part of cancer growth by reducing oxidative DNA alteration. The major forms of vitamin E as an anticancer agent, which acts as major antioxidants to regulate peroxidation reactions and control free-radical production within the body, are tocopherols and tocotrienols. Since Vitamin E had first acted as a non-antioxidant, α-tocopherol has inhibited smooth muscle proliferation activity and protein kinase C activity. Although tocotrienols are mostly investigated as antioxidant effects of tocotrienol, which plays an important role in reducing the damage to DNA by decreasing the by-product of lipid peroxidation. This study aims to investigate the connection between vitamin E and also the risk of breast cancer and the outcome is that some inverse relationship between vitamin E and breast cancer exists. There has been clear evidence that vitamin E reduces the risk of human cancer but our main focus is on breast cancer, seen in many prospective and retrospective case-control, cohort and intervention studies.

Keywords:
Vitamin E, cancer, tocopherols, tocotrienols, epidemiologic studies

Article Details

How to Cite
Haque Ripon, M. S., Asadul Habib, M., Hossain, M., Ahmed, N., Kibria, T., Munira, S., & Hasan, K. (2020). Role of Vitamin E in Prevention of Breast Cancer: An Epidemiological Review. Asian Journal of Advanced Research and Reports, 11(3), 37-47. https://doi.org/10.9734/ajarr/2020/v11i330266
Section
Review Article

References

Hossain MS, Ferdous S, Karim-Kos HE. Breast cancer in South Asia: A Bangladeshi perspective. Cancer epidemiology. 2014;38 (5):465-70.

WHO. Cancer: Breast cancer.

(Accessed: 22 june 2020)

Available:https://www.who.int/cancer/prevention/diagnosis-screening/breast-cancer/en/

Forouzanfar MH, Foreman KJ, Delossantos AM, Lozano R, Lopez AD, Murray CJ, et al. Breast and cervical cancer in 187 countries between 1980 and 2010: A systematic analysis. The lancet. 2011;378(9801):1461-84.

Wilson C, Tobin S, Young R. The exploding worldwide cancer burden. International Journal of Gynecologic Cancer. 2004;14 (1):1-11.

Porter P. Westernizing'' women's risks? Breast cancer in lower-income countries. New England Journal of Medicine. 2008; 358(3):213.

Story H, Love R, Salim R, Roberto A, Krieger J, Ginsburg O. Improving outcomes from breast cancer in a low-income country: lessons from Bangladesh. International Journal of Breast Cancer; 2012.

Ben-Chioma AE, Obunwo CC, Ebirien – Agana BS, Ndokiari B. Some heavy metal assay in urine of breast cancer and breast cancer free patients in Port Harcourt, Nigeria. European Journal of Phar-maceutical and Medical Research. 2017;4 (12):91–95.

Traber MG, Packer L. Vitamin E: beyond antioxidant function. The American journal of clinical nutrition. 1995;62(6):1501S-9S.

Ben-Chioma A, Obunwo C, Ebirien–Agana B, Ndokiari B. Evaluation of heavy metal levels in the serum of breast cancer patients in Port Harcourt, Nigeria. International Journal of Contemporary Medical Research. 2018;4(12):1-5.

Bhattacharya A, Seshadri M, Oven SD, Tóth K, Vaughan MM, Rustum YM. Tumor vascular maturation and improved drug delivery induced by methylselenocysteine leads to therapeutic synergy with anticancer drugs. Clinical Cancer Research. 2008;14 (12):3926-32.

Freeman BA, Crapo JD. Biology of disease: free radicals and tissue injury. Laboratory investigation; A Journal of Technical Methods and Pathology. 1982;47(5):412-26.

Halliwell B, Gutteridge J. Oxygen toxicity, oxygen radicals, transition metals and disease. Biochemical Journal. 1984;219 (1):1.

Dreher D, Junod AF. Role of oxygen free radicals in cancer development. European Journal of cancer. 1996;32(1):30-8.

Halliwell B, Gutteridge JM, Cross CE. Free radicals, antioxidants, and human disease: where are we now? The Journal of laboratory and clinical medicine. 1992;119 (6):598-620.

Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proceedings of the National Academy of Sciences. 1993;90(17):7915-22.

Guyton K, Kensler TW. Oxidative mechanisms in carcinogenesis. British Medical Bulletin. 1993;49(3):523-44.

Feig DI, Reid TM, Loeb LA. Reactive oxygen species in tumorigenesis. Cancer Research. 1994;54(7 Supplement):1890s-4s.

Cerutti PA. Oxy-radicals and cancer. Lancet (British edition). 1994;344(8926):862-3.

Li Y, Li S, Meng X, Gan RY, Zhang JJ, Li HB. Dietary natural products for prevention and treatment of breast cancer. Nutrients. 2017;9(7):728.

Habib MA, Mamun MAA, Kabir MR, Chowdhury MH, Tumpa FA, Nayeem J. Probiotics for cardiovascular diseases, hypertension, hypercholesterolemia and cancer condition: A summary of the evidence. Education Quarterly Reviews. 2019;2(2).

Habib MA, Kawsar Hossen M, Amin A. Anti-Carcinogenic Effect of Lemon & Lemon Products in Cancer Therapy: A Summary of the Evidence; 2019.

Raber-Durlacher J, Weijl N, Saris MA, De Koning B, Zwinderman A, Osanto S. Oral mucositis in patients treated with chemotherapy for solid tumors: a retrospective analysis of 150 cases. Supportive Care in Cancer. 2000;8(5):366-71.

Hartley JA, Reszka K, Lown JW. Photosensitization by antitumor agents, 4. Anthrapyrazole-photosensitized formation of single strand-breaks in DNA. Free Radical Biology and Medicine. 1988;4(6): 337-43.

Pham-Huy LA, He H, Pham-Huy C. Free radicals, antioxidants in disease and health. International Journal of Biomedical Science: IJBS. 2008;4(2):89.

Rao PS, Kalva S, Yerramilli A, Mamidi S. Free radicals and tissue damage: Role of antioxidants. Free Radicals and Antioxidants. 2011;1(4):2-7.

Ratnam DV, Ankola D, Bhardwaj V, Sahana DK, Kumar MR. Role of antioxidants in prophylaxis and therapy: A pharmaceutical perspective. Journal of Controlled Release. 2006;113(3):189-207.

Baum M. Prospects for the chemoprevention of breast cancer. Control of Growth Factors and Prevention of Cancer: Springer. 1992;67-74.

London R, Murphy L, Kitlowski KE. Breast cancer prevention by supplemental vitamin E. Journal of the American College of Nutrition. 1985;4(5):559-64.

Nesaretnam K. Multitargeted therapy of cancer by tocotrienols. Cancer Letters. 2008;269(2):388-95.

Palozza P, Simone R, Picci N, Buzzoni L, Ciliberti N, Natangelo A, et al. RETRACTED: Design, synthesis, and antioxidant potency of novel α-tocopherol analogues in isolated membranes and intact cells. Elsevier; 2008.

Palozza P, Verdecchia S, Avanzi L, Vertuani S, Serini S, Iannone A, et al. Comparative antioxidant activity of tocotrienols and the novel chromanyl-polyisoprenyl molecule FeAox-6 in isolated membranes and intact cells. Molecular and cellular biochemistry. 2006;287(1-2):21-32.

Constantinou C, Papas A, Constantinou AI. Vitamin E and cancer: An insight into the anticancer activities of vitamin E isomers and analogs. International Journal of Cancer. 2008;123(4):739-52.

Traber M, Bowman B, Russell R. Present knowledge in nutrition. Washington, DC: ILSI Press; 2006.

Ju J, Picinich SC, Yang Z, Zhao Y, Suh N, Kong AN, et al. Cancer-preventive activities of tocopherols and tocotrienols. Carcinogenesis. 2010;31(4):533-42.

Eitenmiller RR, Lee J. Vitamin E: food chemistry, composition and analysis: CRC Press; 2004.

Qian J, Morley S, Wilson K, Nava P, Atkinson J, Manor D. Intracellular trafficking of vitamin E in hepatocytes: The role of tocopherol transfer protein. Journal of lipid research. 2005;46(10):2072-82.

Lu G, Xiao H, Li GX, Picinich SC, Chen YK, Liu A, et al. A γ-tocopherol-rich mixture of tocopherols inhibits chemically induced lung tumorigenesis in A/J mice and xenograft tumor growth. Carcinogenesis. 2010;31(4):687-94.

Huang Y, Khor TO, Shu L, Saw CLL, Wu TY, Suh N, et al. A γ-tocopherol-rich mixture of tocopherols maintains Nrf2 expression in prostate tumors of TRAMP mice via epigenetic inhibition of CpG methylation. The Journal of Nutrition. 2012;142(5):818-23.

Barve A, Khor TO, Nair S, Reuhl K, Suh N, Reddy B, et al. γ‐Tocopherol‐enriched mixed tocopherol diet inhibits prostate carcinogenesis in TRAMP mice. International Journal of Cancer. 2009;124 (7):1693-9.

Boscoboinik D, Szewczyk A, Azzi A. α-Tocopherol (vitamin E) regulates vascular smooth muscle cell proliferation and protein kinase C activity. Archives of Biochemistry and Biophysics. 1991;286(1):264-9.

Boscoboinik D, Szewczyk A, Hensey C, Azzi A. Inhibition of cell proliferation by alpha-tocopherol. Role of protein kinase C. Journal of Biological Chemistry. 1991;266 (10):6188-94.

Murphy DJ, Mavis R. Membrane transfer of. cap alpha.-tocopherol: Influence of soluble. cap alpha.-tocopherol-binding factors from the liver, lung, heart and brain of the rat. J Biol Chem; (United States). 1981;256(20).

Brigelius-Flohe R, Traber MG. Vitamin E: function and metabolism. The FASEB Journal. 1999;13(10):1145-55.

Cadenas E, Ginsberg M, Rabe U, Sies H. Evaluation of α-tocopherol antioxidant activity in microsomal lipid peroxidation as detected by low-level chemiluminescence. Biochemical Journal. 1984;223(3):755-9.

Reed DJ, Fariss MW, Pascoe GA. Mechanisms of chemical toxicity and cellular protection systems. Toxicological Sciences. 1986;6(4):591-7.

Pascoe GA, Reed DJ. Vitamin E protection against chemical-induced cell injury: II. Evidence for a threshold effect of cellular α-tocopherol in prevention of adriamycin toxicity. Archives of Biochemistry and Biophysics. 1987;256(1):159-66.

Taylor PR, Qiao Y-L, Abnet CC, Dawsey SM, Yang CS, Gunter EW, et al. Prospective study of serum vitamin E levels and esophageal and gastric cancers. Journal of the National Cancer Institute. 2003;95(18):1414-6.

Mahabir S, Schendel K, Dong YQ, Barrera SL, Spitz MR, Forman MR. Dietary α‐, β‐, γ‐and δ‐tocopherols in lung cancer risk. International Journal of Cancer. 2008;123 (5):1173-80.

Lippman SM, Klein EA, Goodman PJ, Lucia MS, Thompson IM, Ford LG, et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). Jama. 2009;301(1):39-51.

Nesaretnam K, Stephen R, Dils R, Darbre P. Tocotrienols inhibit the growth of human breast cancer cells irrespective of estrogen receptor status. Lipids. 1998;33(5):461.

Sylvester PW, Akl MR, Malaviya A, Parajuli P, Ananthula S, Tiwari RV, et al. Potential role of tocotrienols in the treatment and prevention of breast cancer. Biofactors. 2014;40(1):49-58.

McIntyre BS, Briski KP, Gapor A, Sylvester PW. Antiproliferative and apoptotic effects of tocopherols and tocotrienols on preneoplastic and neoplastic mouse mammary epithelial cells (44544). Proceedings of the Society for Experimental Biology and Medicine. 2000;224(4):292-301.

Shah SJ, Sylvester PW. Tocotrienol-induced cytotoxicity is unrelated to mitochondrial stress apoptotic signaling in neoplastic mammary epithelial cells. Biochemistry and Cell Biology. 2005;83 (1):86-95.

Budin SB, Othman F, Louis SR, Bakar MA, Das S, Mohamed J. The effects of palm oil tocotrienol-rich fraction supplementation on biochemical parameters, oxidative stress and the vascular wall of streptozotocin-induced diabetic rats. Clinics. 2009;64(3): 235-44.

Taridi N, Yahaya MF, Teoh SL, Latiff A, Ngah W, Das S, et al. Tocotrienol rich fraction (TRF) supplementation protects against oxidative DNA damage and improves cognitive functions in Wistar rats. La Clinica Terapeutica. 2011;162(2):93-8.

Sylvester PW, Ip C, Ip MM. Effects of high dietary fat on the growth and development of ovarian-independent carcinogen-induced mammary tumors in rats. Cancer Research. 1986;46(2):763-9.

Sylvester PW, Russell M, Ip MM, Ip C. Comparative effects of different animal and vegetable fats fed before and during carcinogen administration on mammary tumorigenesis, sexual maturation and endocrine function in rats. Cancer Research. 1986;46(2):757-62.

Yu W, Simmons‐Menchaca M, Gapor A, Sanders BG, Kline K. Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols; 1999.

Sylvester P, McIntyre B, Gapor A, Briski K. Vitamin E inhibition of normal mammary epithelial cell growth is associated with a reduction in protein kinase Cα activation. Cell proliferation. 2001;34(6):347-57.

Ray G, Husain SA. Role of lipids, lipoproteins and vitamins in women with breast cancer. Clinical Biochemistry. 2001; 34(1):71-6.

Suzana S, Normah H, Fatimah A, Fadilah RN, Rohi GA, Amin I, et al. Antioxidant intake and status and oxidative stress in relation to breast cancer risk: A case-control study. Asian Pacific J Cancer Prev. 2008;9 (2):343-50.

Negri E, La Vecchia C, Franceschi S, D'Avanzo B, Talamini R, Parpinel M, et al. Intake of selected micronutrients and the risk of breast cancer. International Journal of Cancer. 1996;65(2):140-4.

Freudenheim JL, Marshall JR, Vena JE, Laughlin R, Brasure JR, Swanson MK, et al. Premenopausal breast cancer risk and intake of vegetables, fruits and related nutrients. JNCI: Journal of the National Cancer Institute. 1996;88(6):340-8.

Yang YJ, Hwang SH, Kim HJ, Nam S-J, Kong G, Kim MK. Dietary intake of nitrate relative to antioxidant vitamin in relation to breast cancer risk: A case-control study. Nutrition and Cancer. 2010;62(5):555- 66.

Wald N, Boreham J, Hayward J, Bulbrook R. Plasma retinol, β-carotene and vitamin E levels in relation to the future risk of breast cancer. British Journal of Cancer. 1984;49 (3):321-4.

Knekt P. Serum vitamin E level and risk of female cancers. International Journal of Epidemiology. 1988;17(2):281-6.

Menkes MS, Comstock GW, Vuilleumier JP, Helsing KJ, Rider AA, Brookmeyer R. Serum beta-carotene, vitamins A and E, selenium, and the risk of lung cancer. New England Journal of Medicine. 1986;315(20): 1250-4.

Knekt P, Aromaa A, Maatela J, Alfthan G, Aaran RK, Teppo L, et al. Serum vitamin E, serum selenium and the risk of gastrointestinal cancer. International Journal of Cancer. 1988;42(6):846-50.

Russell M, Thomas B, Bulbrook R. A prospective study of the relationship between serum vitamins A and E and risk of breast cancer. British Journal of Cancer. 1988;57(2):213-5.

Willett WC, Polk BF, Underwood BA, Stampfer MJ, Pressel S, Rosner B, et al. Relation of serum vitamins A and E and carotenoids to the risk of cancer. New England Journal of Medicine. 1984;310 (7): 430-4.

Stryker WS, Stampfer MJ, Stein EA, Kaplan L, Louis TA, Sober A, et al. Diet, plasma levels of beta-carotene and alpha-tocopherol, and risk of malignant melanoma. American Journal of Epidemiology. 1990;131(4):597-611.